Publications
Vanderleest, T.E., Xie, Y., Budhathoki, R., Linvill, K., Hobson, C., Heddleston, J., Loerke, D. and Blankenship, J.T. (2024) Lattice light sheet microscopy reveals 4D force propagation dynamics and leading-edge behaviors in an embryonic epithelium in Drosophila. Current Biology doi:10.1016/j.cub.2024.06.017 (PDF)
De Niz, M., Escobedo García, R., Terán Ramirez, C., Pakowski, Y., Abonza, Y., Bialy, N., Orr, V. L., Olivera, A., Abonza, V., Alleva, K., Allodi, S., Almeida, M. F., Becerril Cuevas, A. R., Bonnet, F., Burgos Solorio, A., Chew, T.-L., Chiabrando, G., Cimini, B., Cleret-Buhot, A., Jiménez, G.C., Daza, L., De Sá, V., De Val, N. Delgado-Álvarez, D.L., Eliceiri, K., Fiolka, R., Grecco, H., Hanein, D., Herrera, P.H., Hockberger, P., Hernandez, H.O., Guadarrama, Y.H., Itano, M., Jacobs, C.A., Jiménez-García, L.F., Sabinina, V.J., Kamaid, A., Keppler, A., Kumar, A., Lacoste, J., Lovy, A., Luby-Phelps, K., Mahadevan-Jansen, A., Malacrida, L., Mehta, S.B., Miller, C., Miranda, K., Moore, J.A., North, A., O'Toole, P., Urbano, M.O., Pietrasanta, L.I., Portugal, R.V., Rossi, A.H., Contreras, J.S., Strambio-De-Castilla, C., Soldevila, G., Vale, B., Vazquez, D., Wood, C., Brown, C.M., Guerrero, A. (2024). Building momentum through networks: Bioimaging across the Americas. J. Microsc. doi:10.1111/jmi.13318 (PDF)
Wright, G.D., Thompson, K.A., Reis, Y., Bischof, J., Hockberger, P.E., Itano, M.S., Yen, L., Adelodun, S.T., Bialy, N., Brown, C.M., Chaabane, L., Chew, T.-L., Chitty, A.I., Cordelières, F.P., De Niz, M., Ellenberg, J., Engelbrecht, L., Fabian-Morales, E., Fazeli, E., Fernandez-Rodriguez, J., Ferrando-May, E., Fletcher, G., Galloway, G.J., Guerrero, A., Guimarães, J.M., Jacobs, C.A., Jayasinghe, S., Kable, E., Kitten, G.T., Komoto, S., Ma, X., Marques, J.A., Millis, B.A., Miranda, K., O'Toole, P.J., Olatunji, S.Y., Paina, F., Pollak, C.N., Prats, C., Pylvänäinen, J.W., Rahmoon, M.A., Reiche, M.A., Riches, J.D., Rossi, A.H., Salamero, J., Thiriet, C., Terjung, S., Vasconcelos, A.d.S., Keppler, A. (2024) Recognising the importance and impact of Imaging Scientists: Global guidelines for establishing career paths within core facilities. J. Microsc. doi:10.1111/jmi.13307 (PDF)
Kumari, R., Ven, K., Chastney, M., Kokate, S.B., Peränen, J., Aaron, J., Kogan, K., Almeida-Souza, L., Kremneva, E., Poincloux, R., Chew, T.-L., Gunning, P.W., Ivaska, J., and Lappalainen, P. (2024). Focal adhesions contain three specialized actin nanoscale layers. Nat. Comm. doi:10.1038/s41467-024-46868-7 (PDF)
Sinclair, R., Wang, M., Jawaid, M.Z., Longkumer, T., Aaron, J. Rossetti, B., Wait, E., McDonald, K., Cox, D., Heddleston, J., Wilkop, T., and Drakakaki, G. (2024) Four-dimensional quantitative analysis of cell plate development using lattice light sheet microscopy identifies robust transition points between growth phases. J. Experimental Botany doi:10.1093/jxb/erae091 (PDF)
Rahmoon, M.A., Hobson, C.M., Aaron, J.S., Balasubramanian, H. and Chew, T.-L. (2024). More than just 'added value': The perils of not establishing shared core facilities in resource-constrained communities. J. Microsc. doi:10.1111/jmi.13277 (PDF)
Lee, R.M., Eisenman, L.R., Khuon, S., Aaron, J.S. and Chew, T.-L. (2024). Believing is seeing – the deceptive influence of bias in quantitative microscopy. J. Cell Sci. doi:10.1242/jcs.261567 (PDF)
Balasubramanian, H., Hobson, C.M., Chew, T.-L., Aaron J.S. (2023) Imagining the future of optical microscopy: everything, everywhere, all at once. Communications Biology. doi:10.1038/s42003-023-05468-9 (PDF)
Roudot, P. Legant, W.R., Zou, Q., Dean, K.M., Isogai, T., Welf, E.S., David, A.F., Gerlich, D.W., Riolka, R., Betzig, E., and Danuser, G. (2023) u-track3D: Measuring, navigating, and validating dense particle trajectories in three dimensions. Cell Reports Methods doi:10.1016/j.crmeth.2023.100655 (PDF)
Reiche, M.A., Jacobs, C.A., Aaron, J.S., Mizrahi, V., Warner, D.F., Chew, T.-L. (2023) A comprehensive strategy to strengthen bioimaging in Africa through the Africa Microscopy Initiative. Nat. Cell. Bio. doi:10.1038/s41556-023-01221-w (PDF)
Gessner, S., Martin, Z.A.-M., Reiche, M.A., Santos, J.A., Dinkele, R., Ramudzuli, A., Dhar, N., de Wet, T.J., Anoosheh, S., Lang, D.M., Aaron, J., Chew, T.-L., Herrmann, J., Müller, R., McKinney, J.D., Woodgate, R., Mizrahi, V., Venclovas, Č., Lamers, M.H., Warner, D.F. (2023) Investigating the composition and recruitment of the mycobacterial ImuA′–ImuB–DnaE2 mutasome. eLife doi:10.7554/eLife.75628 (PDF)
Mulhall, E.M., Gharpure, A., Lee, R.M., Dubin, A.E., Aaron, J.S., Marshall, K.L., Spencer, K.R., Reiche, M.A., Henderson, S.C., Chew, T.-L., Patapoutian, A. (2023) Direct observation of the conformational states of PIEZO1. Nature doi:10.1038/s41586-023-06427-4 (PDF)
Kalbfuss, N., Gönczy, P. (2023) Extensive programmed centriole elimination unveiled in C. elegans embryos. Sci. Adv. doi: 10.1126/sciadv.adg8682 (PDF)
Bharathan, N.K., Giang, W., Hoffman, C.L., Aaron J.S., Khuon, S., Chew, T.-L., Preibisch, S., Trautman, E.T., Heinrich, L., Bogovic, J. Bennett, D., Ackerman, D., Park, W., Petruncio, A., Weigel, A.V., Saalfeld, S., COSEM Project Team, Vogl, A.W., Stahley S.N., Kowalczyk, A.P. (2023) Architecture and dynamics of a desmosome–endoplasmic reticulum complex. Nat. Cell. Bio. doi:10.1038/s41556-023-01154-4 (PDF)
dos Santos, Á., Rollins, D.E., Hari-Gupta, Y., McArthur, H., Du, M., Ru, S.Y.Z., Pidlisna, K., Stranger, A., Lorgat, F., Lambert, D., Brown, I., Howland, K., Aaron, J., Wang, L., Ellis, P.J.I., Chew, T.-L., Martin-Fernandez, M., Pyne, A.L.B., Toseland, C.P. (2023) Autophagy Receptor NDP52 Alters DNA Conformation to Modulate RNA Polymerase II Transcription. Nat. Comm. doi:10.1038/s41467-023-38572-9 (PDF)
Serna-Morales, E., Sánchez-Sánchez, B.J., Marcotti, S., Nichols, A., Bhargava, A., Dragu, A., Hirvonen, L.M., Díaz-de-la-Loza, M., Mink, M., Cox, S., Rayfield, E., Lee, R.M., Hobson, C.M., Chew, T.-L., Stramer, B.M. (2023) Extracellular matrix assembly stress initiates Drosophila central nervous system morphogenesis Dev. Cell doi: 10.1016/j.devcel.2023.03.019 (PDF)
Cartwright, H.N., Hobson, C.M., Chew, T.-L., Reiche, M.A., Aaron, J.S. (2023) The challenges and opportunities of open-access microscopy facilities J. Microsc. doi: 10.1111/jmi.13176 (PDF)
Hobson, C.M., Guo, M., Vishwasrao, H.D., Wu, Y., Shroff, H., Chew, T.-L. (2022) Practical considerations for quantitative light sheet fluorescence microscopy Nat. Meth. doi: 10.1038/s41592-022-01632-x (PDF)
Barger, S.R., Vorselen B., Gauthier, N.C., Theriot, J.A., Krendel, M. (2022) F-actin organization and target constriction during primary macrophage phagocytosis is balanced by competing activity of myosin-I and myosin-II MBoC. doi:10.1091/mbc.E22-06-0210 (PDF)
Damon, L.J., Aaron, J., Palmer, A.E. (2022) Single molecule microscopy to profile the effect of zinc status on transcription factor dynamics Scientific Reports. doi:10.1038/s41598-022-22634-x (PDF)
Carlini, L., Renda, F., Pamula, M.C., Khodjavok, A., Kapoor, T.M. (2022) Coupling of microtubule bundles isolates them from local disruptions to set the structural stability of the anaphase spindle PNAS. doi:10.1073/pnas.2204068119 (PDF)
Herron, J.C., Hu, S., Watanabe, T. Nogueira, A.T., Liu, B., Kern, M.E., Aaron, J., Taylor, A., Pablo, M., Chew, T.-L., Elston, T.C., and Hahn, K.M. (2022) Actin nano-architecture of phagocytic podosomes Nat. Comm. doi:10.1038/s41467-022-32038-0 (PDF)
Parteka-Tojek, Z., Zhu, J., Lee, B., Jodkowska, K., Wang, P., Aaron, J.S., Chew, T.-L., Banecki, K., Plewczynski D., and Ruan., Y. (2022) Super-resolution visualization of chromatin loop folding in human lymphoblastoid cells using interferometric photoactivated localization microscopy Sci. Rep. doi: 10.1038/s41598-022-12568-9 (PDF)
Hari-Gupta, Y. Fili, N., dos Santos A., Cook, A.W., Gough, R.E., Reed, H.C.W., Wang, L., Aaron, J.S., Venit, T., Wait, E., Grosse-Berkenbusch, A., Gebhardt, J.C.M., Percipalle, P., Chew, T.-L., Martin-Fernandez M., and Toseland, C.P., (2022) Myosin VI regulates the spatial organisation of mammalian transcription initiation Nat. Comm. doi: 10.1038/s41467-022-28962-w (PDF)
Colin-York, H., Heddleston, J., Wait, E. Karedla, N., DeSantis, M., Khuon, S., Chew, T.-L., Sbalzarini, I.F., and Fritzsche, F. (2022) Quantifying Molecular Dynamics within Complex Cellular Morphologies using LLSM-FRAP. Small, doi: 10.1002/smtd.202200149 (PDF)
Reiche, M.A., Aaron, J.S., Böhm, U., DeSantis, M., Hobson, C.M., Khuon, S., Lee, R.M, and Chew, T.-L. (2022) When Light Meets Biology: How the Specimen Affects Quantitative Microscopy. J. Cell Sci. doi:10.1242/jcs.259656 (PDF)
Hobson, C.M. and Aaron, J.S. (2022) Combining Multiple Fluorescence Imaging Techniques in Biology: When One Microscope is not Enough. Mol. Biol. Cell. doi: 10.1091/mbc.E21-10-0506 (PDF)
Hobson, C.M., Aaron, J.S., Heddleston, J.M., and Chew T.-L. (2021) Visualizing the Invisible: Advanced Optical Microscopy as a Tool to Measure Biomechanical Forces. Front. Cell Dev. Biol., 9:706126. doi: 10.3389/fcell.2021.706126 (PDF)
Wöllert, T., Langford, G.M. (2022) Super-Resolution Imaging of the Actin Cytoskeleton in Living Cells Using TIRF-SIM. Cytoskeleton doi:10.1007/978-1-0716-1661-1_1 (PDF)
Reiche, M.A., Warner, D.F., Aaron, J., Khuon, S., Fletcher, D.A., Hahn, K., Rogers, K.L., Mhlanga, M., Koch, A., Quaye W., Chew, T.-L. (2021). Imaging Africa: a strategic approach to optical microscopy training in Africa. Nat. Methods, 18(8), 847-855. doi: 10.1038/s41592-021-01227-y (PDF)
Holst, M., Gammelgaard, L., Aaron, J.S., Login, F.H., Rajkumar, S., Hahn, U., Nejsum, L., (2021) Regulated exocytosis: Renal Aquaporin-2 3D Vesicular Network Organization and Association with F-actin Am. J. Physiol. - Cell Physiol doi: 10.1152/ajpcell.00255.2021 (PDF)
Arts, J.J.G., Mahlandt, E.K., Grönloh, M., Schimmel, L., Noordstra, I., Gordon, E., van Steen, A.C.I., Tol, S., Walzog, B., van Rijssel, J., Nolte, M.A., Postma, M., Khuon, S., Heddleston, J.M., Wait, E., Chew, T.-L., Winter, M., Montanez, E., Goedhart, J., van Buul, J.D. (2021) Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration. eLife, doi: 10.7554/eLife.66074 (PDF)
Weigel, A.V., Chang, C.-L., Shtengel, G., Xu, C.S., Hoffman, D.P., Freeman, M., Iyer, N., Aaron, J.S., Khuon, S., Bogovic, J., Qiu, W., Hess, H.F., Lippincott-Schwartz, J. (2021) ER to Golgi protein delivery through an interwoven, tubular network extending from ER. Cell doi: 10.1016/j.cell.2021.03.035 (PDF)
Klappenbach, C.M., Negretti, N.M., Aaron, J.S., Chew, T.-L., Konkel, M.E. (2021) Campylobacter jejuni trigger signaling through host cell focal adhesions to inhibit cell motility and impede wound repair mBio (in press)
Aaron, J.S., Chew, T.-L. (2021) A guide to accurate reporting in digital image processing – can anyone reproduce your quantitative analysis? J. Cell Sci. doi:10.1242/jcs.254151 (PDF) (download supplemental form)
Heddleston, J.M., Aaron, J.S., Khuon, S., Chew, T.-L. (2021) A guide to accurate reporting in digital image acquisition – can anyone replicate your microscopy data? J. Cell Sci. doi: 10.1242/jcs.254144 (PDF) (download supplemental form)
Squyres, G.R., Holmes, M.J., Barger, S.R., Pennycook, B.R., Ryan, J., Yan, V.T., Garner, E.C. (2021) Single-molecule imaging reveals that Z-ring condensation is essential for cell division in Bacillus subtilis Nat. Microbiol. doi:10.1038/s41564-021-00878-z (PDF)
Moore, A. S., Coscia, S. M., Simpson, C. L., Ortega, F. E., Wait, E. C., Heddleston, J. M., Nirschl, J. J., Obara, C. J., Guedes-Dias, P., Boecker, C. A., Chew, T.-L., Theriot, J. A., Lippincott-Schwartz, J. & Holzbaur, E. L. F. (2021) Actin cables and comet tails organize mitochondrial networks in mitosis. Nature doi:10/gh62wc. (PDF)
Morgulis, M., Winter, M.R., Shternhell, L., Gildor, T., & Ben-Tabou de-Leon, S. (2021) VEGF signaling activates the matrix metalloproteinases, MmpL7 and MmpL5 at the sites of active skeletal growth and MmpL7 regulates skeletal elongation. Dev. Bio. doi: 10.1016/j.ydbio.2021.01.013 (PDF)
Winter, M.R., Morgulis, M., Gildor, T., Cohen, A.R., & Ben-Tabou de-Leon, S. (2021) Calcium-vesicles perform active diffusion in the sea urchin embryo during larval biomineralization. PLOS Comp. Bio. doi: 10.1371/journal.pcbi.1008780 (PDF)
Shah, P., Hobson, C. M., Cheng, S., Colville, M. J., Paszek, M. J., Superfine, R. & Lammerding, J. (2020) Nuclear Deformation Causes DNA Damage by Increasing Replication Stress. Current Biology doi:10/gh4t8b. (PDF)
dos Santos, A., Cook, A.W., Gough, R.E., Schilling, M., Olszok, N.A., Brown, I., Wang, L., Aaron, J.S., Martin-Fernandez, M.L., Rehfeldt, F., Toseland, C.P. (2020). DNA damage alters nuclear mechanics through chromatin reorganization. Nucleic Acids Research doi: 10.1093/nar/gkaa1202 (PDF)
Wait, E. C., Reiche, M. A. and Chew, T.-L. (2020). Hypothesis-driven quantitative fluorescence microscopy – the importance of reverse-thinking in experimental design. J. Cell Sci. doi: 10.1242/jcs.250027 (PDF)
Pedrosa, A. T., Murphy, K. N., Nogueira, A. T., Brinkworth, A. J., Thwaites, T. R., Aaron, J., Chew, T,-L., and Carabeo, R. A. (2020). A post-invasion role for Chlamydia type III effector TarP in modulating the dynamics and organization of host cell focal adhesions. J. Biol. Chem., doi: 10.1074/jbc.RA120.015219. (PDF)
Vavrdova, T., Krenek, P., Ovecka, M., Samajova, O., Flokova, P., Illesova, P., Snaurova, R., and Komis, G. (2020) Complementary Superresolution visualization of composite plant microtubule organization and dynamincs. Frontiers in Plant Science. doi: 10.3389/fpls.2020.00693. (PDF)
Chen, Y.-C., Sood, C., Marin, M., Aaron, J.S., Gratton, E., Salaita, K., Melikyan, G.B. (2020) Super-Resolution Fluorescence Imaging Reveals That Serine Incorporator Protein 5 Inhibits Human Immunodeficiency Virus Fusion by Disrupting Envelope Glycoprotein Clusters. ACS Nano doi: 10.1021/acsnano.0c02699 (PDF)
Manley, H.R., Potter, D.L., Heddleston, J.M. , Chew, T.-L., Keightley, M.C., Lieschke, G.J. (2020) Dynamic cellular and subceullular features of migrating leukocytes revealed by in vivo lattice lightsheet microscopy. J. Leukocyte Biology. doi: 10.1002/JLB.3HI0120-589R. (PDF)
Pfisterer, K., Levitt, J., Lawson, C.D., Marsh, R.J., Heddleston, J.M., Wait, E., Ameer-Beg, S.M., Cox, S., and Parsons, M. (2020) FMNL2 regulates dynamics of fascin in filopodia. J. Cell Bio. doi: 10.1083/jcb.201906111 (PDF).
Trzaskoma, P., Ruszczycki, B., Lee, B., Pels, K., Krawczyk, K., Bokota, G., Szczepankiewicz, A., Aaron, J., Walczak, A., Sliwinska, M. , Magalska, A., Kadlof, M., Wolny, A., Parteka, Z., Arabasz, S., Kiss-Arabasz, M., Plewczynski, D., Ruan, Y. (2020) Ultrastructural Visualization of 3D Chromatin Folding Using Volume Electron Microscopy and DNA In Situ Hybridization. Nat. Comm. doi: 10.1038/s41467-020-15987-2 (PDF)
Shannon, M., Pineau, J., Griffie, J., Aaron, J., Peel, T., Williamson, D., Zamoyska, R., Cope, A., Cornish, G., and Owen, D. (2019) Differential nanoscale organisation of LFA-1 modulates T cell migration. J. Cell Sci. doi: 10.1242/jcs.232991 (PDF) .
Stubb, A., Guzman, C., Närvä, E., Aaron, J. Chew, T.-L., Saari, M., Miihkinen, M., Jacquemet, G., and Ivaska, J. (2019) Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells. Nat. Comm.10, 4756. doi:10.1038/s41467-019-12611-w (PDF)
Sato, Y., Hilbert, L., Oda, H., Wan, Y., Heddleston, J.M., Chew, T.-L., Zaburdaev, V., Keller, P., Lionnet, T., Vastenhouw, N., and Kimura, H. (2019) Histone H3K27 acetylation preceding active transcription during zebrafish zygotic genome activation as revealed by live cell analysis. Development. doi: 10.1242/dev.179127 (PDF)
O'Shaughnessy, E., Stone, O., LaFosse, P., Azoitei, M., Tsygankov, D., Heddleston, J.M., Legant, W., Burridge, K., Elston, T., Betzig, E., Chew, T.-L., Adalsteinsson, D., and Hahn, K. (2019) Software for lattice light-sheet imaging of FRET biosensors, illustrated with a new Rap1 biosensor. J. Cell Bio. doi:10.1083/jcb.201903019 (PDF)
Faust, J.J., Balabiyev, A., Heddleston, J.M., Podolnikova, N.P., Baluch, D.P., Chew, T.-L., and Ugarova, T.P. (2019) An actin-based protrusion originating from a podosome-enriched region initiates macrophage fusion. MBoC. doi: 10.1091/mbc.E19-01-0009 (PDF)
Colin-York, H., Javanmardi, Y., Barbieri, L., Li, D., Korobchevskaya, K., Guo, Y., Hall, C., Taylor, A., Khuon, S., Sheridan, G.K., Chew, T-L., Li, D., Moeendarbary, E., and Fritzsche, M. (2019). Spatiotemporally super-resolved volumetric traction force microscopy. Nano Lett. doi: 10.1021/acs.nanolett.9b01196 (PDF)
Klomp, J.E., Shaaya, M., Matsche, J., Rebiai, R., Aaron, J.S., Collins, K.B., Huyot, V., Gonzalez, A.M., Muller, W.A., Chew, T.-L., Malik, A.B., Karginov. A.V. (2019). Time-Variant SRC Kinase Activation Determines Endothelial Permeability Response. Cell Chem. Biol. (26) doi: 10.1016/j.chembiol.2019.04.007 (PDF)
Quinney, K., Frankel, E., Shankar, R., Kasberg, W., Luong, P., and Audhya, A. (2019). Growth factor stimulation promotes multivesicular endosome biogenesis by prolonging recruitment of the late-acting ESCRT machinery. PNAS. (14). doi: 10.1073/pnas.1817898116 (PDF)
Aaron, J., Wait, E., DeSantis, M., and Chew, T-L. (2019). Practical considerations in particle and object tracking and analysis. Current Protocols in Cell Biology. doi: 10.1002/cpcb.88 (PDF)
Tamzalit, F., Wang, M.S., Jin, W., Tello-Lafox, M., Boyko, V., Heddleston, J.M., Black, C.T., Kam, L.C., Huse, M. (2019). Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells. Sci. Immunol. (4). (PDF)
Barger, S., Reillly, N., Shutova, M., Li, Q., Maiuri, P., Heddleston, J.M., Mooseker, M., Flavell, R., Svitkina, T., Oakes, P., Krendel, M., and Gauthier, N. (2019). Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis. Nat. Comm. (10). doi: 10.1038/s41467-019-09104-1 (PDF)
Billaudeau, C., Yao, Z. Cornilleau, C., Carballido-Lopez, R., Chastanet, A. (2019). MreB forms subdiffraction nanofilaments during active growth in Bacillus subtilis. mBio 10(1). doi: 10.1128/mBio.01879-18 (PDF)
Yi, J., Balagopalan, L., Nguyen, T., McIntire, K.M., Samelson, L.E. (2019) TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps. Nat. Comm. (10). doi: 10.1038/s41467-018-08064-2 (PDF)
Kreutzberger, A. J., Ji, M., Aaron, J., Mihaljević, L., & Urban, S. (2019). Rhomboid distorts lipids to break the viscosity-imposed speed limit of membrane diffusion. Science, 363(6426), doi: 10.1126/science.aao0076. (PDF)
Phillips, J. K., Sherman, S. A., Cotton, K. Y., Heddleston, J. M., Taylor, A. B. and Finan, J. D. (2019) Characterization of neurite dystrophy after trauma by high speed structured illumination microscopy and lattice light sheet microscopy. J. Neurosci. Methods. 312: 154-61. doi: 10.1016/j.jneumeth.2018.12.005. (PDF)
Peters, R., Griffie, J., Williamson, D., Aaron, J., Khuon, S., Owen, D., (2019) Development of 2-colour and 3D SMLM data analysis methods for fibrous spatial point patterns. J. Phys. D 52 014005 (PDF)
Wang, H., Rivenson, Y., Jin, Y., Wei, Z., Gao, R., Günaydin, H., Bentolila, L.A., Kural, C., Aydogan, O. (2018) Deep learning enables cross-modality super-resolution in fluorescence microscopy. Nat. Meth. doi: 10.1038/s41592-018-0239-0. (PDF)
Bertiaux, E., Mallet, A., Fort, C., Blisnick, T., Bonnefoy, S., Jung, J., Lemos, M., Marco, S., Vaughan, S., Trépout, S., Tinevez, J.Y., Bastin, P. (2018) Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum. J. Cell Bio. doi: 10.1083/jcb.201805030 (PDF)
Aaron J., Chew TL. (2018) Analysis of Image Similarity and Relationship. In: Jerome W., Price R. (eds) Basic Confocal Microscopy. Springer, Cham (PDF)
Condon, N.D., Heddleston, J.M., Chew, T.L., Luo, L., McPherson, P.S., Ioannou, M.S., Hodgson, L., Stow, J.L., Wall, A.A. (2018) Macropinosome formation by tent pole ruffling in macrophages. J. Cell Bio. doi: 10.1083/jcb.201804137 (PDF)
Padilla-Rodriguez, M., Parker, S.S., Adams, D.G., Westerling, T., Puleo, J.I., Watson, A.W., Hill, S.M., Noon, M., Gaudin, R., Aaron, J., Tong, D., Roe, D.J., Knudsen, B., Mouneimne, G. (2018) The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion. Nat. Comm. 9(2980) 1-16. doi: 10.1038/s41467-018-05367-2 (PDF)
Balagopalan, L., Yi, J., Nguyen, T., McIntire, K.M., Harned, A.S., Narayan, K., Samelson, L.E. (2018) Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation. Nat. Comm. 9(2013) 1-17. doi: 10.1038/s41467-018-04419-x (PDF)
Buttler, C.A., Pezeshkian, N., Fernandez, M.V., Aaron, J.S., Norman, S., Freed, E.O., van Engenlenburg, S.B. (2018). Single molecule fate of HIV-1 Envelope reveals late-stage viral lattice incorporation. Nat. Comm. 9(1) 1861-76. doi: 10.1038/s41467-018-04220-w (PDF)
Faust, J.J., Christenson, W., Doudrick, K., Heddleston, J.M., Chew, T.L., Lampe, M., Balabiyev, A., Ros, R., and Ugarova, T.P. (2018). Fabricating optical-quality glass surfaces to study macrophage fusion. J. Vis. Exp. (133)., doi: 10.3791/56866
Taylor, A.B., Ioannou, M.S., Aaron, J., Chew, T.L. (2018). Model-free quantification and visualization of colocalization in fluorescence images. Cytometry Part A. doi: 10.1002/cyto.a.23356 (PDF)
Moore, T.I., Aaron, J., Chew, T.L., Springer, T.A. (2018). Measuring integrin conformational change on the cell surface with super-resolution microscopy. Cell Reports, 22 (7). 1903-12. Doi: 10.1016/j.celrep.2018.01.062 (PDF)
McArthur, K., Whitehead, L.W., Heddleston, J.M., Li, L., Padman, B.S., Oorschot, V., Geoghegan, N.D., Chappaz, S., Davidson, S., Chin, H.S., Lane, R.M., Dramicanin, M., Saunders, T.L., Sugiana, C., Lessene, R., Osellame, L.D., Chew, T.L., Dewson, G., Lazarou, M., Ramm, G., Lessene, G., Ryan, M.T., Rogers, K.L., van Delft, M.F., and Kile, B.T. (2018). BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. Science, 359. doi: 10.1126/science.aao6047 (PDF)
Matsubayashi, Y., Louani, A., Dragu, A., Sanchez-Sanchez, B.J., Serna-Morales, E., Yolland, L., Gyoergy, A., Vizcay, G., Fleck, R.A., Heddleston, J.M., Chew, T.L., Siekhaus, D.E., and Stramer, B.M. (2017). A moving source of matrix components is essential for de novo basement membrane formation. Current Biology, 27 (22). 3526-34. Doi: 10.1016/j.cub.2017.10.001(PDF)
Mass, T., Drake, J.L., Heddleston, J.M., Falkowski, P.G. (2017). Nanoscale visualization of biomineral formation in coral proto-polyps. Current Biology, 27 (20). 3191-96. Doi: 10.1016/j.cub.2017.09.012 (PDF)
Aaron, J.S., Taylor, A.B., Chew, T.L. (2017). Image co-localization: co-occurrence versus correlation. J. Cell Sci., 131 (3). Doi: 10.1242/jcs.211847 (PDF)
Taylor, A.B. Ioannou, M.S. Watanabe, T., Hahn, K. and Chew, T.L. (2017). Perceptually accurate display of two greyscale images as a single colour image. J. Microscopy, 268(1), 73 - 83. (PDF)
Fritzsche M, Fernandes RA, Chang VT, Colin-York, H., Clausen, M.P., Felce, J.H., Galiani, S., Erlenkamper, C., Santos, A.M., Heddleston, J.M., Pedroza-Pacheco, I., Waithe, D., Bernardino de la Serna, J., Lagerholm, B.C., Liu, T.L., Chew, T.L., Betzig, E., Davis, S.J., and Eggeling, C. (2017). Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation. Science Advances, 3(6), 1 - 18. (PDF)
Griffié, J., Shlomovich, L., Williamson, D. J., Shannon, M., Aaron, J., Khuon, S., Burn, G. L., Boelen, L., Peters, R., Cope, A. P., Cohen, E. A. K., Rubin-Delanchy, P., Owen, D. M. (2017). 3D Bayesian cluster analysis of super-resolution data reveals LAT recruitment to the T cell synapse. Scientific Reports, 7(1), 1 - 9. (PDF)
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Chew, TL, George, R., Soell, A and Betzig, E. (2017) Advanced Imaging Center and lattice light sheet microscope: Opening a path to commercialization. Optics and Photonics News July/August 2017, 42-49. (PDF)
Crowe, L. B., Hughes, P. F., Alcorta, D. A., Osada, T., Smith, A. P., Totzke, J., Loiselle, D.R., Lutz, I.D., Gargesha, M., Roy, D., Roques, J., Darr, D., Lyerly, H.K., Spector, N.L., and Haystead, T.A.J. (2017). A fluorescent Hsp90 probe demonstrates the unique association between extracellular Hsp90 and malignancy in vivo. ACS Chem. Biol., 12(4), 1047 - 1055. (PDF)
Carr, L., Bardet, S. M., Burke, R. C., Arnaud-Cormos, D., Leveque, P., and O'Connor, R. P. (2017). Calcium-independent disruption of microtubule dynamics by nanosecond pulsed electric fields in U87 human glioblastoma cells. Scientific Reports, 7(41267), 1 – 12. (PDF)
Hu, S., Dasbiswas, K., Guo, Z., Tee, Y.-H., Thiagarajan, V., Hersen, P.,Chew, T.L., Safran, S.A., Zaidel-Bar, R., and Bershadsky, A.D. (2017). Long-range self-organization of cytoskeletal myosin II filament stacks. Nature Cell Biol., 19(2), 133 – 141. (PDF)
Abdu, Y., Maniscalco, C., Heddleston, J. M., Chew, T.-L., and Nance, J. (2016). Developmentally programmed germ cell remodelling by endodermal cell cannibalism. Nature Cell Biol., 18(12), 1302 - 1310. (PDF)
Heddleston, J. M., and Chew, T.-L. (2016). Light sheet microscopes: Novel imaging toolbox for visualizing life's processes. The International J. Biochem. & Cell Biol., 80, 119 - 123. (PDF)
Hookway, C., Ding, L., Davidson, M. W., Rappoport, J. Z., Danuser, G., and Gelfand, V. I. (2015). Microtubule-dependent transport and dynamics of vimentin intermediate filaments. Mol. Biol. Cell, 26(9), 1675 - 1686. (PDF)
Xiao, Y., Faucherre, A., Pola-Morell, L., Heddleston, J. M., Liu, T.L., Chew, T.L., Sato, F., Sehara-Fujisawa, Kawakami, K., and Lopez-Schier, H. (2015). High-resolution live imaging reveals axon-glia interactions during peripheral nerve injury and repair in zebrafish. Disease Models & Mechanisms, 8(6), 553 - 564. (PDF)